Gilles de la Tourette syndrome

Gilles de la Tourette syndrome is a neurodevelopmental disorder of the central nervous system that typically emerges during childhood, commonly presenting between ages five and ten with a higher prevalence in males

Gilles de la Tourette syndrome is a neurodevelopmental disorder of the central nervous system that typically emerges during childhood, commonly presenting between ages five and ten with a higher prevalence in males It is clinically defined by the chronic presence of both multiple motor tics and at least one vocal or phonic tic persisting for more than a year, often following a fluctuating, waxing-and-waning course Pathophysiologically, the condition is associated with dysfunction in cortico-stri...

It is clinically defined by the chronic presence of both multiple motor tics and at least one vocal or phonic tic persisting for more than a year, often following a fluctuating, waxing-and-waning course

Pathophysiologically, the condition is associated with dysfunction in cortico-striato-thalamo-cortical brain circuits and altered neurotransmission, predominantly involving dopamine signaling pathways

Patients frequently experience premonitory sensory urges prior to tic execution and often demonstrate psychiatric comorbidities, including attention-deficit/hyperactivity disorder and obsessive-compulsive disorder

Patients frequently experience premonitory sensory urges prior to tic execution and often demonstrate psychiatric comorbidities, including attention-deficit/hyperactivity disorder and obsessive-compulsive disorder