Granuloma inguinale

Granuloma inguinale, also known as donovanosis, is a chronic, progressively destructive sexually transmitted infection caused by the intracellular bacterium *Klebsiella granulomatis* (formerly *Calymmatobacterium granulomatis*) Pathophysiologically, the organism proliferates within mononuclear phagocytes, producing distinctive intracellular inclusions termed Donovan bodies that can lead to extensive tissue destruction, secondary fibrosis, and significant genital scarring if left untreated

Granuloma inguinale, also known as donovanosis, is a chronic, progressively destructive sexually transmitted infection caused by the intracellular bacterium *Klebsiella granulomatis* (formerly *Calymmatobacterium granulomatis*) The condition primarily targets sexually active adults, affecting the skin and mucous membranes of the genital, perineal, and perianal regions Pathophysiologically, the organism proliferates within mononuclear phagocytes, producing distinctive intracellular inclusions ter...