Growth failure associated with Turner's syndrome

Growth failure associated with Turner's syndrome is a primary skeletal and endocrine manifestation characterized by progressive linear growth deceleration and resultant short stature in female pediatric patients The underlying genetic disorder involves complete or partial monosomy of the X chromosome (most commonly 45,X or mosaic variants) The clinical state typically manifests in infancy or early childhood with slowing growth velocity, an absence of the normal pubertal growth spurt due to conco...

Growth failure associated with Turner's syndrome is a primary skeletal and endocrine manifestation characterized by progressive linear growth deceleration and resultant short stature in female pediatric patients

The underlying genetic disorder involves complete or partial monosomy of the X chromosome (most commonly 45,X or mosaic variants) The clinical state typically manifests in infancy or early childhood with slowing growth velocity, an absence of the normal pubertal growth spurt due to concomitant gonadal dysgenesis, and an untreated adult height well below genetic potential

This leads to haploinsufficiency of the short-stature homeobox (SHOX) gene, impairing chondrocyte proliferation and longitudinal bone development

This leads to haploinsufficiency of the short-stature homeobox (SHOX) gene, impairing chondrocyte proliferation and longitudinal bone development

The clinical state typically manifests in infancy or early childhood with slowing growth velocity, an absence of the normal pubertal growth spurt due to concomitant gonadal dysgenesis, and an untreated adult height well below genetic potential