Hairy cell leukemia

Hairy cell leukemia is a rare, indolent B-cell lymphoproliferative neoplasm characterized by the accumulation of mature, abnormal clonal B lymphocytes primarily within the bone marrow, spleen, and peripheral blood It predominantly affects adults, with a marked male predominance and a median age at diagnosis in the mid-fifties Progressive leukemic infiltration of hematopoietic tissue and the splenic red pulp results in bone marrow reticulin fibrosis, pronounced splenomegaly, and cytopenias, parti...

Hairy cell leukemia is a rare, indolent B-cell lymphoproliferative neoplasm characterized by the accumulation of mature, abnormal clonal B lymphocytes primarily within the bone marrow, spleen, and peripheral blood Pathophysiologically, the malignant cells exhibit characteristic fine, hair-like cytoplasmic projections and typically harbor the activating *BRAF* V600E mutation, leading to constitutive MAPK pathway signaling Progressive leukemic infiltration of hematopoietic tissue and the splenic r...

It predominantly affects adults, with a marked male predominance and a median age at diagnosis in the mid-fifties Pathophysiologically, the malignant cells exhibit characteristic fine, hair-like cytoplasmic projections and typically harbor the activating *BRAF* V600E mutation, leading to constitutive MAPK pathway signaling Progressive leukemic infiltration of hematopoietic tissue and the splenic red pulp results in bone marrow reticulin fibrosis, pronounced splenomegaly, and cytopenias, particul...

Pathophysiologically, the malignant cells exhibit characteristic fine, hair-like cytoplasmic projections and typically harbor the activating *BRAF* V600E mutation, leading to constitutive MAPK pathway signaling