Indication

High density lipoprotein deficiency

High density lipoprotein deficiency (hypoalphalipoproteinemia) is a lipid metabolism disorder characterized by abnormally low circulating levels of high-density lipoprotein cholesterol (HDL-C). Read more about High density lipoprotein deficiency

30 drugs 29 manufacturers

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Drugs that treat it

Common High density lipoprotein deficiency therapies.

Showing 1–9 of 30 drugs

NIACIN

HYPERCHOLESTEROLEMIA·+6
GOOD NEIGHBOR

NIACIN

NIACIN/NIACINAMIDE (VITAMIN B-3)·HYPERCHOLESTEROLEMIA·+6
TIME-CAP LABS

NIACIN

NIACIN/NIACINAMIDE (VITAMIN B-3)·HYPERCHOLESTEROLEMIA·+6
NAT'L VIT. CO.

NIACIN

NIACIN/NIACINAMIDE (VITAMIN B-3)·HYPERCHOLESTEROLEMIA·+6
MAGNO-HUMPHRIES

NIACIN

HYPERCHOLESTEROLEMIA·+6
BERGEN BRUNSWIG

NIACIN

HYPERCHOLESTEROLEMIA·+6
GOOD NEIGHBOR

NIACIN

HYPERCHOLESTEROLEMIA·+6
HEALTH MART

NIACIN

HYPERCHOLESTEROLEMIA·+6
SUNMARK
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About High density lipoprotein deficiency.

High density lipoprotein deficiency (hypoalphalipoproteinemia) is a lipid metabolism disorder characterized by abnormally low circulating levels of high-density lipoprotein cholesterol (HDL-C).

Primarily affecting the cardiovascular system, this metabolic state impairs reverse cholesterol transport, significantly increasing the risk of accelerated atherosclerosis and premature coronary artery disease.

It may occur as an acquired condition secondary to insulin resistance, obesity, smoking, or medications, or arise as a primary genetic disorder caused by mutations in genes such as *ABCA1*, *APOA1*, or *LCAT* (as seen in familial HDL deficiency, Tangier disease, and lecithin-cholesterol acyltransferase deficiency).

Depending on the underlying genetic etiology, defining clinical features range from isolated, marked reductions in serum HDL-C to systemic lipid accumulation manifesting as corneal clouding, hepatosplenomegaly, peripheral neuropathy, and tendon or cutaneous xanthomas.

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