Hypertriglyceridemia

Hypertriglyceridemia is a metabolic dyslipidemia defined by elevated fasting serum triglyceride concentrations, conventionally classified as 150 mg/dL or higher Affecting pediatric and adult populations, the condition stems from primary genetic mutations in lipid metabolism or secondary factors, including obesity, poorly controlled type 2 diabetes mellitus, excessive alcohol intake, and specific pharmacotherapies While mild-to-moderate elevations primarily accelerate atherogenesis and heighten t...

Affecting pediatric and adult populations, the condition stems from primary genetic mutations in lipid metabolism or secondary factors, including obesity, poorly controlled type 2 diabetes mellitus, excessive alcohol intake, and specific pharmacotherapies Pathophysiologically, it results from increased hepatic synthesis of very-low-density lipoproteins, impaired peripheral clearance of triglyceride-rich lipoproteins via lipoprotein lipase, or a combination of both

Pathophysiologically, it results from increased hepatic synthesis of very-low-density lipoproteins, impaired peripheral clearance of triglyceride-rich lipoproteins via lipoprotein lipase, or a combination of both

While mild-to-moderate elevations primarily accelerate atherogenesis and heighten the risk of atherosclerotic cardiovascular disease, severe elevations—typically exceeding 500 to 1,000 mg/dL—significantly increase the clinical risk of acute pancreatitis

While mild-to-moderate elevations primarily accelerate atherogenesis and heighten the risk of atherosclerotic cardiovascular disease, severe elevations—typically exceeding 500 to 1,000 mg/dL—significantly increase the clinical risk of acute pancreatitis