Hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy is an inherited cardiovascular disorder most commonly caused by autosomal-dominant mutations in cardiac sarcomere protein genes It is clinically defined by unexplained left ventricular hypertrophy—frequently involving asymmetric septal thickening—and cellular myocyte disarray in the absence of another systemic or cardiac condition capable of producing a similar magnitude of hypertrophy The pathophysiology is characterized by impaired diastolic filling, myocardial isch...

Hypertrophic cardiomyopathy is an inherited cardiovascular disorder most commonly caused by autosomal-dominant mutations in cardiac sarcomere protein genes

It is clinically defined by unexplained left ventricular hypertrophy—frequently involving asymmetric septal thickening—and cellular myocyte disarray in the absence of another systemic or cardiac condition capable of producing a similar magnitude of hypertrophy

The pathophysiology is characterized by impaired diastolic filling, myocardial ischemia, and, in a significant subset of patients, dynamic left ventricular outflow tract obstruction that is often exacerbated by systolic anterior motion of the mitral valve