Hypophosphatemia

Hypophosphatemia is an electrolyte disorder characterized by abnormally low levels of inorganic phosphate in the blood, typically defined in adults as a serum phosphate concentration below 2.5 mg/dL

Hypophosphatemia is an electrolyte disorder characterized by abnormally low levels of inorganic phosphate in the blood, typically defined in adults as a serum phosphate concentration below 2.5 mg/dL It affects multiple organ systems—most notably the musculoskeletal, neurological, cardiac, and respiratory systems—often presenting in hospitalized individuals, critically ill patients, or those with malnutrition, refeeding syndrome, or renal wasting disorders Because phosphate is essential for cellu...

Pathophysiologically, it arises from reduced intestinal absorption, increased urinary excretion, or rapid transcellular shifts of phosphate into cells

Because phosphate is essential for cellular adenosine triphosphate synthesis and cell membrane integrity, deficiency can precipitate muscle weakness, respiratory depression, encephalopathy, rhabdomyolysis, and impaired bone mineralization

Because phosphate is essential for cellular adenosine triphosphate synthesis and cell membrane integrity, deficiency can precipitate muscle weakness, respiratory depression, encephalopathy, rhabdomyolysis, and impaired bone mineralization