Idiopathic parkinsonism

Idiopathic parkinsonism, commonly referred to as idiopathic Parkinson disease, is a chronic, progressive neurodegenerative movement disorder of unknown etiology primarily affecting the central nervous system in older adults It is pathologically characterized by the degeneration of dopaminergic neurons within the substantia nigra pars compacta and the abnormal intraneuronal accumulation of alpha-synuclein into Lewy bodies

Idiopathic parkinsonism, commonly referred to as idiopathic Parkinson disease, is a chronic, progressive neurodegenerative movement disorder of unknown etiology primarily affecting the central nervous system in older adults It is pathologically characterized by the degeneration of dopaminergic neurons within the substantia nigra pars compacta and the abnormal intraneuronal accumulation of alpha-synuclein into Lewy bodies Clinically, the condition is defined by asymmetric motor manifestations—mos...

Clinically, the condition is defined by asymmetric motor manifestations—most notably bradykinesia combined with resting tremor, cogwheel rigidity, and postural instability—often accompanied by nonmotor features such as autonomic dysfunction, sleep disturbances, and cognitive changes