Idiopathic thrombocytopenic purpura

Idiopathic thrombocytopenic purpura, now widely referred to as immune thrombocytopenia, is an acquired hematologic disorder characterized by isolated thrombocytopenia in the absence of an identifiable secondary systemic cause Pathophysiologically, autoantibodies—most commonly immunoglobulin G directed against platelet membrane glycoproteins—lead to premature clearance of circulating platelets by reticuloendothelial macrophages and impaired megakaryocytic thrombopoiesis It affects both pediatric ...

Idiopathic thrombocytopenic purpura, now widely referred to as immune thrombocytopenia, is an acquired hematologic disorder characterized by isolated thrombocytopenia in the absence of an identifiable secondary systemic cause Pathophysiologically, autoantibodies—most commonly immunoglobulin G directed against platelet membrane glycoproteins—lead to premature clearance of circulating platelets by reticuloendothelial macrophages and impaired megakaryocytic thrombopoiesis It affects both pediatric ...

Pathophysiologically, autoantibodies—most commonly immunoglobulin G directed against platelet membrane glycoproteins—lead to premature clearance of circulating platelets by reticuloendothelial macrophages and impaired megakaryocytic thrombopoiesis

It affects both pediatric and adult populations, presenting either acutely—frequently in children following a viral illness—or as a persistent, chronic condition more typical in adults Clinical manifestations range from asymptomatic low platelet counts to mucocutaneous bleeding, petechiae, purpura, ecchymoses, and, less commonly, severe internal hemorrhage