Insulinoma

An insulinoma is a rare, functional neuroendocrine neoplasm that arises from the beta cells of the pancreatic islets While most often sporadic, solitary, and benign, it can occasionally be malignant or occur as a manifestation of multiple endocrine neoplasia type 1 (MEN1) syndrome Pathophysiologically, the tumor autonomously secretes excessive amounts of insulin independent of circulating blood glucose levels, resulting in recurrent fasting or exertional hyperinsulinemic hypoglycemia

An insulinoma is a rare, functional neuroendocrine neoplasm that arises from the beta cells of the pancreatic islets

While most often sporadic, solitary, and benign, it can occasionally be malignant or occur as a manifestation of multiple endocrine neoplasia type 1 (MEN1) syndrome

Pathophysiologically, the tumor autonomously secretes excessive amounts of insulin independent of circulating blood glucose levels, resulting in recurrent fasting or exertional hyperinsulinemic hypoglycemia

Affected individuals commonly present with neuroglycopenic symptoms, such as confusion, visual disturbances, and seizures, as well as sympathoadrenal manifestations including tremors, diaphoresis, and palpitations