Intra-abdominal Clostridium abscess

An intra-abdominal *Clostridium* abscess is a localized, walled-off collection of purulent exudate, necrotic debris, and gas within the peritoneal, retroperitoneal, or visceral abdominal compartments, caused predominantly or in part by anaerobic, spore-forming bacteria of the genus *Clostridium* (most commonly *Clostridium perfringens* or *Clostridium septicum*) Typically occurring as a complication of gastrointestinal tract perforation, penetrating abdominal trauma, anastomotic breakdown, or su...

An intra-abdominal *Clostridium* abscess is a localized, walled-off collection of purulent exudate, necrotic debris, and gas within the peritoneal, retroperitoneal, or visceral abdominal compartments, caused predominantly or in part by anaerobic, spore-forming bacteria of the genus *Clostridium* (most commonly *Clostridium perfringens* or *Clostridium septicum*) Pathophysiologically, anaerobic disruption of tissue facilitates clostridial proliferation and exotoxin release—such as alpha-toxin and...

An intra-abdominal *Clostridium* abscess is a localized, walled-off collection of purulent exudate, necrotic debris, and gas within the peritoneal, retroperitoneal, or visceral abdominal compartments, caused predominantly or in part by anaerobic, spore-forming bacteria of the genus *Clostridium* (most commonly *Clostridium perfringens* or *Clostridium septicum*) Typically occurring as a complication of gastrointestinal tract perforation, penetrating abdominal trauma, anastomotic breakdown, or su...

Patients typically manifest with localized abdominal pain and tenderness, systemic inflammatory signs including persistent fever and leukocytosis, and, if uncontained, a high risk of rapidly progressive sepsis and hemodynamic instability