Major depressive disorder

Major depressive disorder is a common, disabling psychiatric mood disorder primarily affecting the central nervous system across pediatric, adult, and geriatric populations Pathophysiologically, the condition involves complex multifactorial disruptions across monoaminergic neurotransmission, neuroplasticity, inflammatory signaling, and hypothalamic-pituitary-adrenal axis regulation

Major depressive disorder is a common, disabling psychiatric mood disorder primarily affecting the central nervous system across pediatric, adult, and geriatric populations Pathophysiologically, the condition involves complex multifactorial disruptions across monoaminergic neurotransmission, neuroplasticity, inflammatory signaling, and hypothalamic-pituitary-adrenal axis regulation

It is clinically defined by persistent depressed mood or profound anhedonia lasting at least two consecutive weeks, accompanied by significant distress or impairment in social, occupational, and physical functioning Pathophysiologically, the condition involves complex multifactorial disruptions across monoaminergic neurotransmission, neuroplasticity, inflammatory signaling, and hypothalamic-pituitary-adrenal axis regulation

It is clinically defined by persistent depressed mood or profound anhedonia lasting at least two consecutive weeks, accompanied by significant distress or impairment in social, occupational, and physical functioning Diagnostic features include alterations in sleep and appetite, psychomotor agitation or retardation, fatigue, impaired concentration, inappropriate feelings of worthlessness or guilt, and recurrent suicidal ideation

Diagnostic features include alterations in sleep and appetite, psychomotor agitation or retardation, fatigue, impaired concentration, inappropriate feelings of worthlessness or guilt, and recurrent suicidal ideation