Malignant hyperthermia

Malignant hyperthermia is a rare, life-threatening pharmacogenetic disorder of skeletal muscle characterized by a fulminant hypermetabolic state triggered primarily by volatile inhalational anesthetics or the depolarizing neuromuscular blocker succinylcholine This sustained calcium overload drives continuous skeletal muscle contraction, marked glycogenolysis, and profound cellular metabolism, clinically producing refractory hypercapnia, generalized muscle rigidity, tachycardia, severe metabolic ...

Malignant hyperthermia is a rare, life-threatening pharmacogenetic disorder of skeletal muscle characterized by a fulminant hypermetabolic state triggered primarily by volatile inhalational anesthetics or the depolarizing neuromuscular blocker succinylcholine

Primarily affecting genetically susceptible pediatric and adult surgical patients—most often carrying mutations in the ryanodine receptor gene (*RYR1*)—the condition results from uncontrolled intracellular calcium release from the sarcoplasmic reticulum This sustained calcium overload drives continuous skeletal muscle contraction, marked glycogenolysis, and profound cellular metabolism, clinically producing refractory hypercapnia, generalized muscle rigidity, tachycardia, severe metabolic and re...

Primarily affecting genetically susceptible pediatric and adult surgical patients—most often carrying mutations in the ryanodine receptor gene (*RYR1*)—the condition results from uncontrolled intracellular calcium release from the sarcoplasmic reticulum

Primarily affecting genetically susceptible pediatric and adult surgical patients—most often carrying mutations in the ryanodine receptor gene (*RYR1*)—the condition results from uncontrolled intracellular calcium release from the sarcoplasmic reticulum