Indication

Meningeal leukemia

Meningeal leukemia, also referred to as leukemic meningitis or leukemic leptomeningitis, is a serious complication characterized by the metastatic infiltration of leukemic cells into the leptomeninges and cerebrospinal fluid of the central nervous system. Read more about Meningeal leukemia

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About Meningeal leukemia.

Meningeal leukemia, also referred to as leukemic meningitis or leukemic leptomeningitis, is a serious complication characterized by the metastatic infiltration of leukemic cells into the leptomeninges and cerebrospinal fluid of the central nervous system.

While it can emerge in any acute or chronic leukemia, it most frequently affects pediatric and adult patients with acute lymphoblastic leukemia and high-risk acute myeloid leukemia.

Pathophysiologically, leukemic blasts cross the blood-brain or blood-cerebrospinal fluid barrier to seed the subarachnoid space, leading to meningeal inflammation, disrupted cerebrospinal fluid dynamics, and potential cranial nerve involvement.

Clinically, this state manifests with features of increased intracranial pressure and neuroaxis dysfunction, including headaches, nausea, vomiting, altered mental status, seizures, and focal neurological deficits.

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