Meningitis due to anthrax

Meningitis due to anthrax is a severe, rapidly progressive central nervous system infection resulting from hematogenous dissemination of *Bacillus anthracis* to the leptomeninges and brain parenchyma

Meningitis due to anthrax is a severe, rapidly progressive central nervous system infection resulting from hematogenous dissemination of *Bacillus anthracis* to the leptomeninges and brain parenchyma

It can develop as a life-threatening complication of any primary form of anthrax—such as cutaneous, inhalational, or gastrointestinal infection—or occasionally present as the initial manifestation of systemic disease Clinically, affected individuals present acutely with high fevers, severe headache, meningismus, nausea, altered mental status, and focal neurologic deficits or seizures, with cerebrospinal fluid analysis typically revealing grossly bloody fluid and elevated opening pressures

It can develop as a life-threatening complication of any primary form of anthrax—such as cutaneous, inhalational, or gastrointestinal infection—or occasionally present as the initial manifestation of systemic disease Pathophysiologically, bacterial proliferation and potent exotoxin release trigger intense vascular destruction, extensive cerebral edema, and a hallmark hemorrhagic meningoencephalitis

Pathophysiologically, bacterial proliferation and potent exotoxin release trigger intense vascular destruction, extensive cerebral edema, and a hallmark hemorrhagic meningoencephalitis Clinically, affected individuals present acutely with high fevers, severe headache, meningismus, nausea, altered mental status, and focal neurologic deficits or seizures, with cerebrospinal fluid analysis typically revealing grossly bloody fluid and elevated opening pressures

Clinically, affected individuals present acutely with high fevers, severe headache, meningismus, nausea, altered mental status, and focal neurologic deficits or seizures, with cerebrospinal fluid analysis typically revealing grossly bloody fluid and elevated opening pressures