Metastatic castration-sensitive prostate cancer

Metastatic castration-sensitive prostate cancer is an advanced stage of malignancy originating in the male prostate gland that has disseminated beyond regional pelvic lymph nodes to distant sites, most commonly the skeleton, non-regional lymph nodes, or visceral organs

Metastatic castration-sensitive prostate cancer is an advanced stage of malignancy originating in the male prostate gland that has disseminated beyond regional pelvic lymph nodes to distant sites, most commonly the skeleton, non-regional lymph nodes, or visceral organs Consequently, patients remain functionally responsive to androgen suppression, whether they are treatment-naive or previously exposed to medical or surgical castration without having developed disease progression at castrate level...

The defining pathophysiologic feature of this clinical state is the continued dependence of the metastatic tumor cells on androgen receptor signaling pathways for survival and proliferation

Consequently, patients remain functionally responsive to androgen suppression, whether they are treatment-naive or previously exposed to medical or surgical castration without having developed disease progression at castrate levels of serum testosterone