Mixed epilepsy

Mixed epilepsy—formally categorized in modern neurological classifications as combined generalized and focal epilepsy—is a clinical disorder of the central nervous system characterized by the concurrent or independent occurrence of both focal-onset and generalized-onset seizures in the same patient Pathophysiologically, it involves widespread neural network hyperexcitability alongside discrete, localized epileptogenic foci, typically demonstrated on electroencephalography by the presence of both...

It frequently manifests in pediatric populations and individuals with severe developmental and epileptic encephalopathies, such as Lennox-Gastaut syndrome, though it can affect individuals of any age

It frequently manifests in pediatric populations and individuals with severe developmental and epileptic encephalopathies, such as Lennox-Gastaut syndrome, though it can affect individuals of any age

Pathophysiologically, it involves widespread neural network hyperexcitability alongside discrete, localized epileptogenic foci, typically demonstrated on electroencephalography by the presence of both generalized spike-and-wave discharges and focal interictal epileptiform abnormalities