Muscle spasticity of cerebral origin

Muscle spasticity of cerebral origin is a chronic motor impairment within upper motor neuron syndrome, resulting specifically from injury or pathology localized to the brain rather than the spinal cord It commonly affects pediatric and adult populations with cerebral palsy, traumatic brain injury, ischemic or hemorrhagic stroke, or hypoxic-ischemic encephalopathy

Muscle spasticity of cerebral origin is a chronic motor impairment within upper motor neuron syndrome, resulting specifically from injury or pathology localized to the brain rather than the spinal cord Pathophysiologically, disruption of descending corticospinal and reticulospinal inhibitory pathways causes disinhibition and hyper-excitability of spinal stretch reflex arcs Clinically, it is characterized by a velocity-dependent increase in tonic stretch reflexes and muscle resistance to passive ...

It commonly affects pediatric and adult populations with cerebral palsy, traumatic brain injury, ischemic or hemorrhagic stroke, or hypoxic-ischemic encephalopathy Clinically, it is characterized by a velocity-dependent increase in tonic stretch reflexes and muscle resistance to passive movement, often accompanied by clonus, involuntary spasms, impaired voluntary motor control, and increased risk of joint contractures

Pathophysiologically, disruption of descending corticospinal and reticulospinal inhibitory pathways causes disinhibition and hyper-excitability of spinal stretch reflex arcs

Clinically, it is characterized by a velocity-dependent increase in tonic stretch reflexes and muscle resistance to passive movement, often accompanied by clonus, involuntary spasms, impaired voluntary motor control, and increased risk of joint contractures