Myasthenia gravis

Myasthenia gravis is a chronic autoimmune neuromuscular junction disorder characterized by fluctuating weakness and abnormal fatigability of voluntary skeletal muscles The condition is mediated primarily by pathogenic autoantibodies directed against acetylcholine receptors or related proteins at the postsynaptic motor endplate, disrupting normal neuromuscular transmission Clinically, symptoms typically worsen with repeated muscle use and improve with rest, frequently involving the ocular, bulbar...

Myasthenia gravis is a chronic autoimmune neuromuscular junction disorder characterized by fluctuating weakness and abnormal fatigability of voluntary skeletal muscles Clinically, symptoms typically worsen with repeated muscle use and improve with rest, frequently involving the ocular, bulbar, limb, or respiratory muscles Presentations range from localized ocular manifestations, such as ptosis and diplopia, to severe generalized weakness that can culminate in life-threatening respiratory failure...

The condition is mediated primarily by pathogenic autoantibodies directed against acetylcholine receptors or related proteins at the postsynaptic motor endplate, disrupting normal neuromuscular transmission