Myxedema coma

Myxedema coma is a rare, life-threatening endocrine emergency representing the decompensated extreme of severe, longstanding hypothyroidism It primarily affects older adults, particularly elderly women, and involves widespread multiorgan system failure triggered when homeostatic adaptations collapse, often precipitated by systemic infection, cold exposure, trauma, surgery, or central nervous system depressants Pathophysiologically driven by profound cellular thyroid hormone deficiency, it is cli...

Myxedema coma is a rare, life-threatening endocrine emergency representing the decompensated extreme of severe, longstanding hypothyroidism Pathophysiologically driven by profound cellular thyroid hormone deficiency, it is clinically defined by altered sensorium—ranging from lethargy and confusion to stupor or frank coma—alongside severe hypothermia, bradycardia, hypoventilation with hypercapnia, hypotension, and generalized mucopolysaccharide tissue infiltration leading to classic nonpitting my...

It primarily affects older adults, particularly elderly women, and involves widespread multiorgan system failure triggered when homeostatic adaptations collapse, often precipitated by systemic infection, cold exposure, trauma, surgery, or central nervous system depressants Pathophysiologically driven by profound cellular thyroid hormone deficiency, it is clinically defined by altered sensorium—ranging from lethargy and confusion to stupor or frank coma—alongside severe hypothermia, bradycardia, ...

It primarily affects older adults, particularly elderly women, and involves widespread multiorgan system failure triggered when homeostatic adaptations collapse, often precipitated by systemic infection, cold exposure, trauma, surgery, or central nervous system depressants

Pathophysiologically driven by profound cellular thyroid hormone deficiency, it is clinically defined by altered sensorium—ranging from lethargy and confusion to stupor or frank coma—alongside severe hypothermia, bradycardia, hypoventilation with hypercapnia, hypotension, and generalized mucopolysaccharide tissue infiltration leading to classic nonpitting myxedematous edema