Indication

Nesidioblastosis

Nesidioblastosis is a rare endocrine pancreatic condition characterized by the abnormal neoformation, hyperplasia, and functional dysregulation of insulin-secreting beta cells originating from the pancreatic ductal epithelium. Read more about Nesidioblastosis

3 drugs 3 manufacturers

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Drugs that treat it

Common Nesidioblastosis therapies.

Showing 1–3 of 3 drugs

DIAZOXIDE

VASODILATORS·INSULINOMA·+2
E5 PHARMA

DIAZOXIDE

VASODILATORS·INSULINOMA·+2
PAR HEALTH USA,
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About Nesidioblastosis.

Nesidioblastosis is a rare endocrine pancreatic condition characterized by the abnormal neoformation, hyperplasia, and functional dysregulation of insulin-secreting beta cells originating from the pancreatic ductal epithelium.

It affects the endocrine system across pediatric populations—where it classically underlies persistent congenital hyperinsulinism in infants—and less commonly presents in adults either idiopathically or secondary to bariatric procedures such as Roux-en-Y gastric bypass.

Histopathologically defined by enlarged, pleomorphic beta-cell clusters and ductuloinsular complexes, the disorder can occur in focal or diffuse distributions throughout the pancreas.

Clinically, it manifests as persistent endogenous hyperinsulinemic hypoglycemia, resulting in neuroglycopenic symptoms and autonomic distress in the absence of a localized insulinoma.

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