Niacin deficiency

Niacin deficiency is a nutritional and metabolic disorder resulting from an inadequate supply of vitamin B3 (nicotinic acid and nicotinamide) or its amino acid precursor, tryptophan Because niacin is an essential component of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), its depletion impairs cellular oxidation-reduction reactions, energy metabolism, and DNA repair across multiple organ systems

Niacin deficiency is a nutritional and metabolic disorder resulting from an inadequate supply of vitamin B3 (nicotinic acid and nicotinamide) or its amino acid precursor, tryptophan Although primary nutritional deficiency is uncommon in developed regions, secondary deficiency frequently affects individuals with chronic alcohol use disorder, malabsorptive syndromes, carcinoid tumors, or inborn errors of amino acid transport such as Hartnup disease

Niacin deficiency is a nutritional and metabolic disorder resulting from an inadequate supply of vitamin B3 (nicotinic acid and nicotinamide) or its amino acid precursor, tryptophan Because niacin is an essential component of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), its depletion impairs cellular oxidation-reduction reactions, energy metabolism, and DNA repair across multiple organ systems Although primary nutritional deficienc...

Although primary nutritional deficiency is uncommon in developed regions, secondary deficiency frequently affects individuals with chronic alcohol use disorder, malabsorptive syndromes, carcinoid tumors, or inborn errors of amino acid transport such as Hartnup disease Clinically, severe deficiency culminates in pellagra, a systemic condition classically characterized by photosensitive dermatitis, gastrointestinal disturbances including intractable diarrhea, and progressive neuropsychiatric manif...

Although primary nutritional deficiency is uncommon in developed regions, secondary deficiency frequently affects individuals with chronic alcohol use disorder, malabsorptive syndromes, carcinoid tumors, or inborn errors of amino acid transport such as Hartnup disease