Non-radiographic axial spondyloarthritis

Non-radiographic axial spondyloarthritis is a chronic inflammatory rheumatic disease that primarily affects the axial skeleton, notably the sacroiliac joints and the spine, as well as peripheral entheses and joints

Non-radiographic axial spondyloarthritis is a chronic inflammatory rheumatic disease that primarily affects the axial skeleton, notably the sacroiliac joints and the spine, as well as peripheral entheses and joints It predominantly develops in young adults and is characterized clinically by persistent inflammatory back pain and stiffness that improve with activity but not with rest

It predominantly develops in young adults and is characterized clinically by persistent inflammatory back pain and stiffness that improve with activity but not with rest

Pathophysiologically, it shares underlying autoimmune and genetic features—such as HLA-B27 positivity—with ankylosing spondylitis, but it is definitively distinguished by active inflammation visible on magnetic resonance imaging or elevated systemic inflammatory markers in the absence of definitive radiographic structural sacroiliitis on plain X-rays

Pathophysiologically, it shares underlying autoimmune and genetic features—such as HLA-B27 positivity—with ankylosing spondylitis, but it is definitively distinguished by active inflammation visible on magnetic resonance imaging or elevated systemic inflammatory markers in the absence of definitive radiographic structural sacroiliitis on plain X-rays

Pathophysiologically, it shares underlying autoimmune and genetic features—such as HLA-B27 positivity—with ankylosing spondylitis, but it is definitively distinguished by active inflammation visible on magnetic resonance imaging or elevated systemic inflammatory markers in the absence of definitive radiographic structural sacroiliitis on plain X-rays