Osteoporosis

Osteoporosis is a systemic skeletal disorder characterized by low bone mass, deterioration of bone microarchitecture, and increased bone fragility Although it can affect individuals of any age or sex, it most commonly arises in postmenopausal women and older adults due to age-related bone loss, estrogen deficiency, or secondary causes such as chronic glucocorticoid therapy and endocrine disorders Pathophysiologically, an imbalance where osteoclast-mediated bone resorption outpaces osteoblast-med...

Osteoporosis is a systemic skeletal disorder characterized by low bone mass, deterioration of bone microarchitecture, and increased bone fragility Although it can affect individuals of any age or sex, it most commonly arises in postmenopausal women and older adults due to age-related bone loss, estrogen deficiency, or secondary causes such as chronic glucocorticoid therapy and endocrine disorders Often clinically silent until a low-energy trauma occurs, it predisposes patients to pathological fr...

Although it can affect individuals of any age or sex, it most commonly arises in postmenopausal women and older adults due to age-related bone loss, estrogen deficiency, or secondary causes such as chronic glucocorticoid therapy and endocrine disorders Pathophysiologically, an imbalance where osteoclast-mediated bone resorption outpaces osteoblast-mediated bone formation leads to diminished bone mineral density and compromised mechanical strength Often clinically silent until a low-energy trauma...