Postexposure plague prophylaxis

Postexposure plague prophylaxis refers to the preventative antimicrobial management of asymptomatic individuals following documented or suspected exposure to the Gram-negative bacterium *Yersinia pestis* This clinical indication applies to populations with high-risk encounters, such as close contact with patients or animals exhibiting pneumonic plague, direct contact with infectious body fluids or tissues, laboratory accidents, or potential exposure following an intentional aerosolized bioterror...

Postexposure plague prophylaxis refers to the preventative antimicrobial management of asymptomatic individuals following documented or suspected exposure to the Gram-negative bacterium *Yersinia pestis* This clinical indication applies to populations with high-risk encounters, such as close contact with patients or animals exhibiting pneumonic plague, direct contact with infectious body fluids or tissues, laboratory accidents, or potential exposure following an intentional aerosolized bioterror...

This clinical indication applies to populations with high-risk encounters, such as close contact with patients or animals exhibiting pneumonic plague, direct contact with infectious body fluids or tissues, laboratory accidents, or potential exposure following an intentional aerosolized bioterrorism release

Pathophysiologically, preventive therapy aims to eradicate inoculating bacteria during the incubation period before the organism disseminates to produce fulminant respiratory failure in pneumonic plague, severe lymphatic necrosis in bubonic plague, or overwhelming endotoxemia and multiorgan failure in septicemic plague