Premenstrual dysphoric disorder

Premenstrual dysphoric disorder is a severe, cyclical neuroendocrine and affective condition affecting individuals during their reproductive years It is characterized by disabling psychological and somatic symptoms—predominantly marked irritability, depressed mood, affective lability, anxiety, fatigue, and physical discomfort—that emerge predictably during the late luteal phase of the menstrual cycle and resolve shortly after menses begins Pathophysiologically, the disorder involves an atypical ...

Premenstrual dysphoric disorder is a severe, cyclical neuroendocrine and affective condition affecting individuals during their reproductive years

It is characterized by disabling psychological and somatic symptoms—predominantly marked irritability, depressed mood, affective lability, anxiety, fatigue, and physical discomfort—that emerge predictably during the late luteal phase of the menstrual cycle and resolve shortly after menses begins

It is characterized by disabling psychological and somatic symptoms—predominantly marked irritability, depressed mood, affective lability, anxiety, fatigue, and physical discomfort—that emerge predictably during the late luteal phase of the menstrual cycle and resolve shortly after menses begins

Pathophysiologically, the disorder involves an atypical central nervous system sensitivity to normal physiological fluctuations in ovarian steroids, leading to secondary dysregulation of central serotonergic signaling and GABA-A receptor modulation by neurosteroids such as allopregnanolone

Pathophysiologically, the disorder involves an atypical central nervous system sensitivity to normal physiological fluctuations in ovarian steroids, leading to secondary dysregulation of central serotonergic signaling and GABA-A receptor modulation by neurosteroids such as allopregnanolone