Prevention of NSAID-induced gastric ulcer

The prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcer refers to prophylactic clinical strategies aimed at reducing the risk of mucosal erosions and ulcerations within the stomach lining during therapy with NSAIDs

The prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcer refers to prophylactic clinical strategies aimed at reducing the risk of mucosal erosions and ulcerations within the stomach lining during therapy with NSAIDs This condition primarily affects the upper gastrointestinal system in individuals requiring short- or long-term NSAID therapy, particularly high-risk groups such as older adults or those with a prior history of peptic ulcer disease Pathophysiologically, tra...

This condition primarily affects the upper gastrointestinal system in individuals requiring short- or long-term NSAID therapy, particularly high-risk groups such as older adults or those with a prior history of peptic ulcer disease

Pathophysiologically, traditional NSAIDs disrupt mucosal defenses by inhibiting cyclooxygenase-mediated synthesis of cytoprotective prostaglandins, diminishing gastric mucus and bicarbonate secretion, impairing mucosal blood flow, and exerting direct topical cellular injury, which collectively leaves the gastric epithelium vulnerable to acid-peptic digestion and severe complications such as hemorrhage or perforation