Indication

Prevention of Rh isoimmunization at first-trimester pregnancy termination

Prevention of Rh isoimmunization at first-trimester pregnancy termination refers to immunoprophylaxis aimed at halting maternal antibody development against the RhD red blood cell antigen following elective, medical, or surgical abortion before 12 to 14 weeks of gestation. Read more about Prevention of Rh isoimmunization at first-trimester pregnancy termination

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About Prevention of Rh isoimmunization at first-trimester pregnancy termination.

Prevention of Rh isoimmunization at first-trimester pregnancy termination refers to immunoprophylaxis aimed at halting maternal antibody development against the RhD red blood cell antigen following elective, medical, or surgical abortion before 12 to 14 weeks of gestation.

In an unsensitized, Rh-negative pregnant female carrying an Rh-positive embryo or fetus, disruption of the maternal-fetal interface during pregnancy termination can cause feto-maternal hemorrhage.

Exposure to foreign fetal Rh antigens stimulates the maternal adaptive immune system to produce anti-D immunoglobulin antibodies.

Although this immune sensitization is generally clinically silent during the initial pregnancy event, maternal circulating anti-D IgG can cross the placenta in subsequent Rh-incompatible gestations, resulting in immune-mediated hemolytic disease of the fetus and newborn.

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