Primary ovarian failure

Primary ovarian failure, historically termed premature ovarian failure and increasingly referred to as primary ovarian insufficiency, is an endocrine and reproductive disorder defined by the depletion or dysfunction of ovarian follicles before 40 years of age

Primary ovarian failure, historically termed premature ovarian failure and increasingly referred to as primary ovarian insufficiency, is an endocrine and reproductive disorder defined by the depletion or dysfunction of ovarian follicles before 40 years of age It directly affects females of reproductive age, leading to impaired fertility and systemic sequelae from diminished sex steroid production Pathophysiologically, the condition is characterized by hypergonadotropic hypoestrogenism, classical...

Primary ovarian failure, historically termed premature ovarian failure and increasingly referred to as primary ovarian insufficiency, is an endocrine and reproductive disorder defined by the depletion or dysfunction of ovarian follicles before 40 years of age It directly affects females of reproductive age, leading to impaired fertility and systemic sequelae from diminished sex steroid production Etiologies include chromosomal abnormalities, autoimmune oophoritis, iatrogenic injury from chemothe...

Pathophysiologically, the condition is characterized by hypergonadotropic hypoestrogenism, classically manifesting as oligomenorrhea or amenorrhea accompanied by low serum estradiol and elevated follicle-stimulating hormone levels

Pathophysiologically, the condition is characterized by hypergonadotropic hypoestrogenism, classically manifesting as oligomenorrhea or amenorrhea accompanied by low serum estradiol and elevated follicle-stimulating hormone levels Etiologies include chromosomal abnormalities, autoimmune oophoritis, iatrogenic injury from chemotherapy or radiation, and idiopathic causes, predisposing patients to early bone loss and cardiovascular morbidity