Psoriasis

Psoriasis is a chronic, immune-mediated inflammatory disorder primarily affecting the integumentary system, though it can involve extracutaneous tissues such as the joints While it can present across any age group, it is frequently associated with systemic inflammatory comorbidities, including psoriatic arthritis, cardiometabolic disease, and psychological distress

Psoriasis is a chronic, immune-mediated inflammatory disorder primarily affecting the integumentary system, though it can involve extracutaneous tissues such as the joints

Pathophysiologically driven by dysregulated innate and adaptive immune signaling—predominantly along the interleukin-23 and interleukin-17 pathways—it leads to marked keratinocyte hyperproliferation, abnormal epidermal differentiation, and local neoangiogenesis

Pathophysiologically driven by dysregulated innate and adaptive immune signaling—predominantly along the interleukin-23 and interleukin-17 pathways—it leads to marked keratinocyte hyperproliferation, abnormal epidermal differentiation, and local neoangiogenesis While it can present across any age group, it is frequently associated with systemic inflammatory comorbidities, including psoriatic arthritis, cardiometabolic disease, and psychological distress

Pathophysiologically driven by dysregulated innate and adaptive immune signaling—predominantly along the interleukin-23 and interleukin-17 pathways—it leads to marked keratinocyte hyperproliferation, abnormal epidermal differentiation, and local neoangiogenesis Clinically, it most frequently manifests as sharply demarcated, erythematous plaques covered by silvery-white scales that favor extensor surfaces, the scalp, and the lumbosacral region, although clinical variants include guttate, pustular...

Clinically, it most frequently manifests as sharply demarcated, erythematous plaques covered by silvery-white scales that favor extensor surfaces, the scalp, and the lumbosacral region, although clinical variants include guttate, pustular, inverse, and erythrodermic presentations

Clinically, it most frequently manifests as sharply demarcated, erythematous plaques covered by silvery-white scales that favor extensor surfaces, the scalp, and the lumbosacral region, although clinical variants include guttate, pustular, inverse, and erythrodermic presentations

While it can present across any age group, it is frequently associated with systemic inflammatory comorbidities, including psoriatic arthritis, cardiometabolic disease, and psychological distress