Pulmonary arterial hypertension

Pulmonary arterial hypertension is a rare, progressive cardiovascular disorder classified as Group 1 pulmonary hypertension that affects the precapillary pulmonary arterial vasculature It is characterized by pathological vascular remodeling, vasoconstriction, endothelial cell proliferation, and thrombosis within the small pulmonary arteries These structural changes progressively elevate pulmonary vascular resistance and arterial pressure, increasing right ventricular afterload and eventually lea...

It is characterized by pathological vascular remodeling, vasoconstriction, endothelial cell proliferation, and thrombosis within the small pulmonary arteries

These structural changes progressively elevate pulmonary vascular resistance and arterial pressure, increasing right ventricular afterload and eventually leading to right-sided heart failure and death Patients typically present with exertional dyspnea, fatigue, chest pain, syncope, and peripheral edema, and the condition can arise idiopathically, heritably, or secondary to connective tissue diseases, congenital heart defects, or certain drugs and toxins

Patients typically present with exertional dyspnea, fatigue, chest pain, syncope, and peripheral edema, and the condition can arise idiopathically, heritably, or secondary to connective tissue diseases, congenital heart defects, or certain drugs and toxins