Pyridoxine deficiency

Pyridoxine deficiency is a nutritional and metabolic disorder characterized by inadequate tissue levels of vitamin B6 and its biologically active coenzyme form, pyridoxal 5'-phosphate The condition predominantly affects the neurological, dermatologic, and hematologic systems across various populations, often arising secondary to malabsorption, chronic alcohol use disorder, end-stage renal disease, or the use of pyridoxine-inactivating medications such as isoniazid

Pyridoxine deficiency is a nutritional and metabolic disorder characterized by inadequate tissue levels of vitamin B6 and its biologically active coenzyme form, pyridoxal 5'-phosphate

The condition predominantly affects the neurological, dermatologic, and hematologic systems across various populations, often arising secondary to malabsorption, chronic alcohol use disorder, end-stage renal disease, or the use of pyridoxine-inactivating medications such as isoniazid Pathophysiologically, impaired coenzyme activity disrupts amino acid metabolism, heme biosynthesis, and neurotransmitter synthesis—notably gamma-aminobutyric acid Clinical manifestations typically include peripheral...

Pathophysiologically, impaired coenzyme activity disrupts amino acid metabolism, heme biosynthesis, and neurotransmitter synthesis—notably gamma-aminobutyric acid Clinical manifestations typically include peripheral neuropathy, altered mental status, and intractable seizures, alongside microcytic or sideroblastic anemia, glossitis, cheilosis, and seborrheic dermatitis

Pathophysiologically, impaired coenzyme activity disrupts amino acid metabolism, heme biosynthesis, and neurotransmitter synthesis—notably gamma-aminobutyric acid