Pyrimethamine toxicity

Pyrimethamine toxicity is an adverse clinical state resulting from supratherapeutic exposure to, or acute poisoning from, the antiparasitic agent pyrimethamine

Pyrimethamine toxicity is an adverse clinical state resulting from supratherapeutic exposure to, or acute poisoning from, the antiparasitic agent pyrimethamine As a competitive inhibitor of dihydrofolate reductase, high drug levels interfere with folic acid metabolism and primarily affect rapidly dividing tissues—particularly the hematopoietic and central nervous systems Clinically, toxicity presents with dose-dependent bone marrow suppression leading to megaloblastic anemia, leukopenia, and thr...

As a competitive inhibitor of dihydrofolate reductase, high drug levels interfere with folic acid metabolism and primarily affect rapidly dividing tissues—particularly the hematopoietic and central nervous systems Clinically, toxicity presents with dose-dependent bone marrow suppression leading to megaloblastic anemia, leukopenia, and thrombocytopenia, as well as gastrointestinal distress, mouth ulcers, ataxia, tremors, and potentially fatal generalized seizures, with pediatric patients and fola...

As a competitive inhibitor of dihydrofolate reductase, high drug levels interfere with folic acid metabolism and primarily affect rapidly dividing tissues—particularly the hematopoietic and central nervous systems