Refractory aspergillosis

Refractory aspergillosis refers to an invasive fungal infection caused by *Aspergillus* species that fails to respond or demonstrates clinical progression despite receiving guideline-directed, therapeutic-dose antifungal therapy for an adequate duration Primarily manifesting in the lower respiratory tract and adjacent thoracic tissues, it most commonly arises in severely immunocompromised hosts, such as recipients of hematopoietic stem cell or solid organ transplants, individuals with prolonged ...

Refractory aspergillosis refers to an invasive fungal infection caused by *Aspergillus* species that fails to respond or demonstrates clinical progression despite receiving guideline-directed, therapeutic-dose antifungal therapy for an adequate duration Clinically and pathophysiologically, the condition is characterized by persistent or worsening symptoms, radiographic progression of angioinvasive tissue necrosis or cavitary lesions, and persistently positive or rising mycological biomarkers suc...

Primarily manifesting in the lower respiratory tract and adjacent thoracic tissues, it most commonly arises in severely immunocompromised hosts, such as recipients of hematopoietic stem cell or solid organ transplants, individuals with prolonged neutropenia, or patients undergoing intensive antineoplastic chemotherapy

Clinically and pathophysiologically, the condition is characterized by persistent or worsening symptoms, radiographic progression of angioinvasive tissue necrosis or cavitary lesions, and persistently positive or rising mycological biomarkers such as serum or bronchoalveolar lavage galactomannan