Relapsing fever

Relapsing fever is an acute, systemic vector-borne infectious disease caused by spirochetes of the genus *Borrelia*, transmitted to humans via the bites of soft or hard ticks or through contact with infected body lice

Relapsing fever is an acute, systemic vector-borne infectious disease caused by spirochetes of the genus *Borrelia*, transmitted to humans via the bites of soft or hard ticks or through contact with infected body lice The illness primarily affects the vascular and reticuloendothelial systems, producing sudden, high febrile episodes accompanied by rigors, severe headache, myalgia, and arthralgia Pathophysiologically, the condition is defined by multiphasic cycles of high-grade spirochetemia alter...

The illness primarily affects the vascular and reticuloendothelial systems, producing sudden, high febrile episodes accompanied by rigors, severe headache, myalgia, and arthralgia Severe clinical states may culminate in a critical defervescence crisis characterized by profound diaphoresis, systemic hypotension, or fatal cardiovascular collapse

The illness primarily affects the vascular and reticuloendothelial systems, producing sudden, high febrile episodes accompanied by rigors, severe headache, myalgia, and arthralgia Pathophysiologically, the condition is defined by multiphasic cycles of high-grade spirochetemia alternating with afebrile periods, driven by rapid multiphasic antigenic variation of the pathogen's surface proteins that repeatedly circumvents host humoral immunity

Pathophysiologically, the condition is defined by multiphasic cycles of high-grade spirochetemia alternating with afebrile periods, driven by rapid multiphasic antigenic variation of the pathogen's surface proteins that repeatedly circumvents host humoral immunity