Indication

Restless leg syndrome

Restless leg syndrome, also known as Willis-Ekbom disease, is a common neurological sensorimotor disorder affecting the central nervous system, most frequently presenting in middle-aged and older adults with a higher prevalence in females. Read more about Restless leg syndrome

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About Restless leg syndrome.

Restless leg syndrome, also known as Willis-Ekbom disease, is a common neurological sensorimotor disorder affecting the central nervous system, most frequently presenting in middle-aged and older adults with a higher prevalence in females.

It is characterized by an irresistible urge to move the lower limbs, typically provoked by uncomfortable dysesthesias or paresthesias that worsen during periods of rest or inactivity and peak in severity during the evening or night.

Movement provides temporary symptom relief, and the condition often results in significant sleep disruption alongside periodic limb movements of sleep.

Pathophysiologically, the disorder is linked to central dopaminergic dysfunction and impaired brain iron homeostasis, occurring either idiopathically—frequently with a genetic component—or secondary to conditions such as iron deficiency, end-stage renal disease, or pregnancy.

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