Indication

Rheumatic fever prevention

Rheumatic fever prevention encompasses primary prophylaxis to avert an initial attack of acute rheumatic fever following group A streptococcal pharyngitis, as well as secondary continuous prophylaxis to prevent recurrent attacks in patients with a documented history of acute rheumatic fever or established rheumatic heart disease. Read more about Rheumatic fever prevention

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About Rheumatic fever prevention.

Rheumatic fever prevention encompasses primary prophylaxis to avert an initial attack of acute rheumatic fever following group A streptococcal pharyngitis, as well as secondary continuous prophylaxis to prevent recurrent attacks in patients with a documented history of acute rheumatic fever or established rheumatic heart disease.

Acute rheumatic fever is a nonsuppurative, autoimmune inflammatory sequela provoked by *Streptococcus pyogenes* infection, predominantly affecting school-aged children and adolescents.

Pathophysiologically driven by molecular mimicry, the condition impacts multiple organ systems, most notably presenting with carditis and permanent valvular damage, as well as migratory polyarthritis, Sydenham chorea, subcutaneous nodules, and erythema marginatum.

Prevention strategies target this post-infectious immune response to halt the onset or progressive worsening of chronic rheumatic heart disease and valvulitis.

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