Skin and skin structure Clostridium infection

A skin and skin structure *Clostridium* infection is a bacterial infection of the cutaneous, subcutaneous, fascial, or deeper muscular tissues caused by anaerobic, spore-forming species of the genus *Clostridium*, most notably *Clostridium perfringens*

A skin and skin structure *Clostridium* infection is a bacterial infection of the cutaneous, subcutaneous, fascial, or deeper muscular tissues caused by anaerobic, spore-forming species of the genus *Clostridium*, most notably *Clostridium perfringens* Clinical presentations range from localized anaerobic cellulitis to life-threatening necrotizing soft-tissue infections and myonecrosis (gas gangrene)

A skin and skin structure *Clostridium* infection is a bacterial infection of the cutaneous, subcutaneous, fascial, or deeper muscular tissues caused by anaerobic, spore-forming species of the genus *Clostridium*, most notably *Clostridium perfringens* These infections typically arise following traumatic injury, surgical contamination, puncture wounds, or vascular compromise that creates an anaerobic tissue environment Clinical presentations range from localized anaerobic cellulitis to life-thre...

These infections typically arise following traumatic injury, surgical contamination, puncture wounds, or vascular compromise that creates an anaerobic tissue environment

Pathophysiologically, the condition is driven by the rapid elaboration of destructive exotoxins and enzymes—such as alpha-toxin—which precipitate microvascular thrombosis, severe tissue necrosis, gas production manifesting as crepitus, and fulminant systemic toxicity or shock

Pathophysiologically, the condition is driven by the rapid elaboration of destructive exotoxins and enzymes—such as alpha-toxin—which precipitate microvascular thrombosis, severe tissue necrosis, gas production manifesting as crepitus, and fulminant systemic toxicity or shock

Pathophysiologically, the condition is driven by the rapid elaboration of destructive exotoxins and enzymes—such as alpha-toxin—which precipitate microvascular thrombosis, severe tissue necrosis, gas production manifesting as crepitus, and fulminant systemic toxicity or shock