Squamous cell carcinoma of vulva

Squamous cell carcinoma of the vulva is an invasive epithelial malignancy arising from the stratified squamous epithelium of the female external genitalia, predominantly affecting the labia majora and labia minora It represents the vast majority of vulvar cancers and typically affects postmenopausal individuals, though it also occurs in younger populations Clinically, it typically presents with persistent vulvar pruritus, pain, ulceration, or a visible exophytic or nodular mass that may bleed or...

It represents the vast majority of vulvar cancers and typically affects postmenopausal individuals, though it also occurs in younger populations Pathophysiologically, the disease develops through two main pathways: a human papillomavirus (HPV)–dependent route driven by persistent high-risk HPV infection, or an HPV-independent route commonly associated with chronic inflammatory dermatoses, such as lichen sclerosus, and frequent TP53 mutations

It represents the vast majority of vulvar cancers and typically affects postmenopausal individuals, though it also occurs in younger populations

Pathophysiologically, the disease develops through two main pathways: a human papillomavirus (HPV)–dependent route driven by persistent high-risk HPV infection, or an HPV-independent route commonly associated with chronic inflammatory dermatoses, such as lichen sclerosus, and frequent TP53 mutations

Clinically, it typically presents with persistent vulvar pruritus, pain, ulceration, or a visible exophytic or nodular mass that may bleed or cause localized discharge