Syphilis

Syphilis is a systemic, chronic infection caused by the spirochete bacterium *Treponema pallidum*, transmitted predominantly through direct sexual contact with infectious lesions or vertically from mother to fetus during pregnancy

Syphilis is a systemic, chronic infection caused by the spirochete bacterium *Treponema pallidum*, transmitted predominantly through direct sexual contact with infectious lesions or vertically from mother to fetus during pregnancy Without effective intervention, dissemination leads to secondary syphilis, characterized by generalized mucocutaneous lesions, diffuse lymphadenopathy, and palms-and-soles rash, followed by an asymptomatic latent period

The disease progresses through distinct clinical stages, beginning with primary syphilis, classically manifested by a painless ulcer or chancre at the inoculation site Without effective intervention, dissemination leads to secondary syphilis, characterized by generalized mucocutaneous lesions, diffuse lymphadenopathy, and palms-and-soles rash, followed by an asymptomatic latent period If left untreated, late or tertiary syphilis can emerge years later, causing destructive gummatous disease, card...

The disease progresses through distinct clinical stages, beginning with primary syphilis, classically manifested by a painless ulcer or chancre at the inoculation site

Without effective intervention, dissemination leads to secondary syphilis, characterized by generalized mucocutaneous lesions, diffuse lymphadenopathy, and palms-and-soles rash, followed by an asymptomatic latent period

If left untreated, late or tertiary syphilis can emerge years later, causing destructive gummatous disease, cardiovascular complications, or neurosyphilis involving the central nervous system

If left untreated, late or tertiary syphilis can emerge years later, causing destructive gummatous disease, cardiovascular complications, or neurosyphilis involving the central nervous system