Systemic-onset juvenile idiopathic arthritis

Systemic-onset juvenile idiopathic arthritis is a severe, rare subtype of juvenile idiopathic arthritis that primarily affects children younger than 16 years of age Clinically, it is characterized by chronic or recurring arthritis accompanied by prominent systemic manifestations, including quotidian high-spiking fevers, an evanescent salmon-pink maculopapular rash, generalized lymphadenopathy, hepatosplenomegaly, and serositis

Systemic-onset juvenile idiopathic arthritis is a severe, rare subtype of juvenile idiopathic arthritis that primarily affects children younger than 16 years of age

Pathophysiologically categorized as an autoinflammatory disorder rather than a classical autoimmune disease, it is driven by dysregulated innate immune pathways and high levels of pro-inflammatory cytokines, notably interleukin-1 and interleukin-6

Pathophysiologically categorized as an autoinflammatory disorder rather than a classical autoimmune disease, it is driven by dysregulated innate immune pathways and high levels of pro-inflammatory cytokines, notably interleukin-1 and interleukin-6 Clinically, it is characterized by chronic or recurring arthritis accompanied by prominent systemic manifestations, including quotidian high-spiking fevers, an evanescent salmon-pink maculopapular rash, generalized lymphadenopathy, hepatosplenomegaly, ...

Pathophysiologically categorized as an autoinflammatory disorder rather than a classical autoimmune disease, it is driven by dysregulated innate immune pathways and high levels of pro-inflammatory cytokines, notably interleukin-1 and interleukin-6