Indication

T3 suppression for thyroid function test

"T3 suppression for thyroid function test" refers to a dynamic diagnostic procedure rather than a distinct primary disease entity. Read more about T3 suppression for thyroid function test

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About T3 suppression for thyroid function test.

"T3 suppression for thyroid function test" refers to a dynamic diagnostic procedure rather than a distinct primary disease entity.

It evaluates the endocrine feedback mechanism of the hypothalamic-pituitary-thyroid axis in patients undergoing evaluation for suspected autonomous thyroid hyperactivity, mild or borderline hyperthyroidism, or to differentiate between resistance to thyroid hormone and thyrotropin-secreting pituitary adenomas.

Pathophysiologically, the administration of exogenous triiodothyronine (T3) normally exerts negative feedback on the anterior pituitary gland, markedly decreasing thyrotropin secretion and subsequent radioactive iodine uptake or endogenous thyroxine production.

A failure of endogenous thyroid hormone or radioiodine uptake to suppress indicates autonomous thyroid functioning tissue independent of normal pituitary control.

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