Tetanus

Tetanus is an acute, potentially life-threatening neurotoxin-mediated disease caused by the anaerobic bacterium *Clostridium tetani*, whose spores enter the body through breaches in the skin The pathogen secretes tetanospasmin, an exotoxin that travels via retrograde axonal transport to the central nervous system, where it cleaves synaptobrevin and blocks the release of inhibitory neurotransmitters, predominantly GABA and glycine This disruption leads to disinhibited alpha motor neuron activity,...

Tetanus is an acute, potentially life-threatening neurotoxin-mediated disease caused by the anaerobic bacterium *Clostridium tetani*, whose spores enter the body through breaches in the skin This disruption leads to disinhibited alpha motor neuron activity, producing generalized skeletal muscle rigidity, painful reflex spasms, and autonomic instability

Tetanus is an acute, potentially life-threatening neurotoxin-mediated disease caused by the anaerobic bacterium *Clostridium tetani*, whose spores enter the body through breaches in the skin

The pathogen secretes tetanospasmin, an exotoxin that travels via retrograde axonal transport to the central nervous system, where it cleaves synaptobrevin and blocks the release of inhibitory neurotransmitters, predominantly GABA and glycine

This disruption leads to disinhibited alpha motor neuron activity, producing generalized skeletal muscle rigidity, painful reflex spasms, and autonomic instability The condition most severely affects unvaccinated individuals, neonates, and older adults with waning immunity, classically presenting with trismus (lockjaw), risus sardonicus, and opisthotonos

The condition most severely affects unvaccinated individuals, neonates, and older adults with waning immunity, classically presenting with trismus (lockjaw), risus sardonicus, and opisthotonos

The condition most severely affects unvaccinated individuals, neonates, and older adults with waning immunity, classically presenting with trismus (lockjaw), risus sardonicus, and opisthotonos