Tularemia

Tularemia is an acute, potentially severe zoonotic infectious disease caused by the facultative intracellular Gram-negative bacterium *Francisella tularensis* The infection typically involves the lymphatic, integumentary, respiratory, or gastrointestinal systems following transmission through arthropod bites, direct contact with infected animal tissues, ingestion of contaminated water or food, or inhalation of infective aerosols Pathophysiologically, the organism targets macrophages, suppressing...

Tularemia is an acute, potentially severe zoonotic infectious disease caused by the facultative intracellular Gram-negative bacterium *Francisella tularensis*

The infection typically involves the lymphatic, integumentary, respiratory, or gastrointestinal systems following transmission through arthropod bites, direct contact with infected animal tissues, ingestion of contaminated water or food, or inhalation of infective aerosols

Pathophysiologically, the organism targets macrophages, suppressing immune responses and disseminating systemically to produce acute febrile illness characterized by distinct clinical forms, most commonly ulceroglandular disease with cutaneous ulceration and regional lymphadenopathy, as well as glandular, oculoglandular, oropharyngeal, pneumonic, or typhoidal presentations