Vasculitis

Vasculitis refers to a heterogeneous group of inflammatory diseases characterized by immune-mediated inflammation and necrosis of blood vessel walls The condition can compromise any segment of the circulatory network—including large, medium, and small arteries, veins, and capillaries—and may affect isolated organs or manifest as a multiorgan systemic disorder across pediatric and adult populations

Vasculitis refers to a heterogeneous group of inflammatory diseases characterized by immune-mediated inflammation and necrosis of blood vessel walls

The condition can compromise any segment of the circulatory network—including large, medium, and small arteries, veins, and capillaries—and may affect isolated organs or manifest as a multiorgan systemic disorder across pediatric and adult populations Pathophysiologically, inflammatory cell infiltration and transmural injury cause vascular wall thickening, stenosis, occlusion, or thrombosis, resulting in downstream tissue ischemia and infarction, or structural weakening that precipitates aneurys...

The condition can compromise any segment of the circulatory network—including large, medium, and small arteries, veins, and capillaries—and may affect isolated organs or manifest as a multiorgan systemic disorder across pediatric and adult populations Pathophysiologically, inflammatory cell infiltration and transmural injury cause vascular wall thickening, stenosis, occlusion, or thrombosis, resulting in downstream tissue ischemia and infarction, or structural weakening that precipitates aneurys...

Pathophysiologically, inflammatory cell infiltration and transmural injury cause vascular wall thickening, stenosis, occlusion, or thrombosis, resulting in downstream tissue ischemia and infarction, or structural weakening that precipitates aneurysm formation and hemorrhage

Clinical presentations range from constitutional features, such as fever, fatigue, and weight loss, to severe organ-specific manifestations, including palpable purpura, glomerulonephritis, alveolar hemorrhage, and ischemic neuropathy

Clinical presentations range from constitutional features, such as fever, fatigue, and weight loss, to severe organ-specific manifestations, including palpable purpura, glomerulonephritis, alveolar hemorrhage, and ischemic neuropathy