Vitamin E deficiency

Vitamin E deficiency is a nutritional deficit characterized by inadequate physiological levels of alpha-tocopherol, the primary biologically active form of this fat-soluble antioxidant It most commonly affects individuals with severe lipid malabsorption disorders, such as cystic fibrosis, cholestatic liver disease, or abetalipoproteinemia, as well as premature low-birth-weight infants and individuals with rare genetic mutations in the alpha-tocopherol transfer protein Pathophysiologically, the l...

Vitamin E deficiency is a nutritional deficit characterized by inadequate physiological levels of alpha-tocopherol, the primary biologically active form of this fat-soluble antioxidant Pathophysiologically, the lack of antioxidant protection leads to membrane lipid peroxidation and cell destruction, presenting clinically with spinocerebellar ataxia, peripheral neuropathy, loss of proprioception and vibratory sensation, skeletal myopathy, and hemolytic anemia

It most commonly affects individuals with severe lipid malabsorption disorders, such as cystic fibrosis, cholestatic liver disease, or abetalipoproteinemia, as well as premature low-birth-weight infants and individuals with rare genetic mutations in the alpha-tocopherol transfer protein