Wilms' tumor

Wilms' tumor, also known as nephroblastoma, is a primary malignant embryonal renal neoplasm that predominantly affects young children, typically presenting before five years of age

Wilms' tumor, also known as nephroblastoma, is a primary malignant embryonal renal neoplasm that predominantly affects young children, typically presenting before five years of age Pathophysiologically, it arises from persistent metanephric blastema and classically demonstrates a triphasic histology comprising blastemal, epithelial, and stromal cell lineages, often associated with genetic alterations such as mutations or deletions in the *WT1* gene Clinically, affected patients most commonly pre...

Clinically, affected patients most commonly present with an asymptomatic, firm, unilateral abdominal mass, which may be accompanied by abdominal pain, hematuria, hypertension, or systemic symptoms such as fever