Clinical intelligence & editorial.

PubMed

Resolution of Nail Abnormalities in Psoriatic Arthritis.

A 63-year-old man with a 20-year history of severe onychodystrophy and subungual hyperkeratosis presented with a one month of inflammatory arthritis primarily affecting the wrists and hands and left knee enthesitis. In addition to remarkable nail abnormalities, dactylitis was noted in the fingers of the left hand (Picture A). The patient had no history of cutaneous psoriasis. Inflammatory markers were elevated, while rheumatoid factor and anti-cyclic citrullinated peptide antibodies were negativ...

Psoriatic Arthritis

Sugimoto T• January 15, 2026

PubMed

PROMISE‑MINO: A Prospective, Open‑Label, Multicenter, Single‑Arm, Phase IV Study of the Safety, Local Tolerability, and Efficacy of Topical Minocycline Hydrochloride 4% Gel in Indian Patients With Moderate‑to‑Severe Acne Vulgaris.

Background/objectives: With increasing resistance to clindamycin, minocycline shows low resistance rates in Cutibacterium acnes. Topical minocycline 4% foam was approved in the USA (2019) and as a gel formulation in India (2022) for moderate-to-severe acne vulgaris (AV). However, there is a paucity of clinical data regarding the use of topical minocycline in acne. This study was conducted to assess the safety, tolerability, and efficacy of topical minocycline 4% gel in Indian patients. Methods:...

Acne Vulgaris

Viswanath V, Pradhan S, Bhura M, Gupta R, Suryatale P, Banguru H, De A, Sonkar V, Bhushan S, Gadkari R, Dhoot D, Balasubramanian A, Patil S, Barkate H• January 15, 2026

PubMed

Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE)-Like Presentation in a Case of Systemic Contact Dermatitis to Paraphenylenediamine (PPD).

Paraphenylenediamine (PPD) is an aromatic amine that was first manufactured in Germany by Hofmann in 1833. It is primarily employed for its antioxidant and staining properties and is found in rubber goods, printer ink, photographic supplies, textiles and footwear, henna tattoos, and hair dyes. As it is a prehapten that can cross the skin barrier easily, it can be detected in plasma, urine, and faeces after application of hair dye within half an hour. The molecular properties of PPD allow hair dy...

Contact Dermatitis

Sushantika S, Nanda S, Sethi J, Phulware RH• January 15, 2026

PubMed

Antioxidant, biochemical, hematological indices and handling stress resistance in rainbow trout (Oncorhynchus mykiss) fed with diets supplemented with nano-selenium and vitamin C.

Use of various nanoparticles and vitamins to strengthen the immune system of fish to improve growth and biochemical indice, and to mitigate the harmful effects of free radicals through enhanced antioxidant enzyme activity has become the subject of numerous studies. In this study, fish with an average weight of 55.20 ± 7.90 g, after a two-week acclimation period, were randomly distributed into 18 polyethylene 300-L tanks, with 25 fish per tank. The experiment consisted of six treatments with thre...

Selenium

Momeni F, Meshkini S, Imani A• January 15, 2026

PubMed

Short-Term Choroidal and Retinal Structural Changes in Myopic Children Treated with 0.05% Atropine.

Purpose To evaluate daily 0.05% atropine’s effects on structural changes in the choroid and retina in myopic children. Methods This prospective cohort study included 100 children aged 6–15 years, of whom 83 completed 6-month follow-up. Participants received either nightly 0.05% atropine eyedrops or no pharmacologic treatment (all wore single-vision spectacles). Spherical equivalent (SE) and axial length (AL) were measured, and swept-source OCT angiography was used to assess choroidal thicknes...

Atropine

Yang Y, Luo Z, Wen L, Gao W, Deng Y, Tang X, Yang Z, Li X• January 15, 2026

PubMed

Off-Label Ustekinumab and Vedolizumab in Pediatric Anti-TNFα Refractory IBD: Therapeutic Drug Monitoring Insights from a Case Series.

Background: Vedolizumab and ustekinumab are increasingly used off-label in pediatric inflammatory bowel disease (IBD) unresponsive or refractory to anti–TNFα therapy. Despite their increasing use in clinical practice, evidence in the pediatric population remains limited, especially regarding therapeutic exposure thresholds and the clinical utility of therapeutic drug monitoring (TDM). Methods: We report a series of five pediatric cases with Crohn’s disease or ulcerative colitis treated with uste...

Ustekinumab

Cheli S, Mosini G, Battini V, Carnovale C, Radice S, Lebiu M, Cattoni A, Zuin G, Clementi E• January 15, 2026

PubMed

Long-lasting hypoglycemia through insulin degludec during acute kidney injury after diabetic ketoacidosis: A case report.

Abstract. Diabetic ketoacidosis (DKA) may be complicated by acute kidney injury (AKI). While the pharmacokinetics of insulin degludec were previously suggested to be stable even in chronic kidney disease, its safety profile in acute or dynamic renal dysfunction remains unclear. We herein report a 13-yr-old boy with severe DKA complicated by AKI, who developed prolonged hypoglycemia after switching from continuous intravenous regular insulin to subcutaneous insulin aspart and insulin degludec. I...

Insulin Degludec

Kawashima S, Suzuki T, Shima H, Suzuki D, Kamimura M, Kikuchi A, Kanno J• January 15, 2026

PubMed

Alumanyl silanides as multifunctional reagents for olefin cycloaddition, CO hydrosilylation, and reductive CO coupling.

Alumanyl silanides represent a rare class of main group complexes, characterized by an anionic Al–Si bond, stabilized through an intimate ion pair. Computations revealed pronounced multiple-bond character in these alumanyl silanides, which is further enhanced upon counter ion sequestration. Despite these electronic features, such bonding motifs remain largely unexplored in experimental chemistry. In this work, we investigate the reactivity of a sodium alumanyl silanide, stabilized by bulky silyl...

Reagents

Ludwig M, Voigtland J, Vasko P, Stigler S, Inoue S• January 15, 2026

PubMed

Interrelationships among handgrip strength, body composition, physical activity, and quality of life in adults with cystic fibrosis: A cross-sectional study.

Abstract Background In individuals with cystic fibrosis (CF), lean mass and muscle strength are important predictors of clinical outcomes. This study evaluated associations among body composition, handgrip strength, muscle quality, physical activity, and health‐related quality of life in CF. Methods This observational, cross‐sectional study included 27 adults with CF and 24 age‐matched healthy controls. Body composition was assessed using dual‐energy x‐ray absorptiometry, physical activity b...

Body Composition

Crain BH, Harris C, Bellissimo MP, Gonzalez Ramirez LA, Ivie EA, Hunt WR, Tangpricha V, Ziegler TR, Harris RA, Alvarez JA• January 15, 2026

PubMed

Active guidance in ultrasound bladder scanning using reinforcement learning.

Accurate measurement of bladder volume is essential for diagnosing urinary retention and voiding dysfunction. However, finding optimal view can be challenging for less experienced operators, potentially leading to suboptimal imaging and potential misdiagnoses. This study proposes an intelligent guidance system leveraging reinforcement learning (RL) to improve the acquisition of ultrasound images in ultrasound bladder scanning procedure. We introduce a novel pipeline that incorporates a practical...

Bladder Scanning

Hsu HL, Zahiri M, Li GY, Mukaddim RA, Lee H, Wilson MG, Grube J, Schmidt S, Ghoshal G, Raju B• January 15, 2026

PubMed

Diagnostic Limitations of Hemoglobin A1c in the Setting of Compound Hemoglobinopathy: A Case Report of Sickle Cell Disease, Alpha Thalassemia, and Occult Diabetes.

This case report illustrates the diagnostic limitations of hemoglobin A1c (HbA1c) in patients with coexisting hemoglobinopathies. Sickle cell disease (SCD) and alpha thalassemia are inherited disorders characterized by chronic anemia and altered red blood cell turnover, both of which can significantly interfere with the accuracy of HbA1c measurements. In such cases, HbA1c may appear falsely low, potentially delaying the diagnosis and treatment of diabetes mellitus. We describe a 63-year-old fema...

A1c

Toperzer K, Moon A• January 15, 2026

PubMed

Correlates of body image in individuals with endometriosis: The role of body compassion and endometriosis-related symptoms.

Knowledge pertaining to the interplay between body image, body compassion, and endometriosis-related symptoms is limited. The current study aimed to elucidate the relationships between body compassion, body image, and endometriosis-related symptoms, and explore whether endometriosis-related factors or body compassion are significant correlates of body image. Individuals with self-reported symptomatic endometriosis (n = 261), aged 18 years and over, provided endometriosis-related information and...

Endometriosis

Van Niekerk L, Ng CHM, Gibson L, O'Hara R, Mikocka-Walus A, Norris K, Leonardi M, Armour M, Evans S• January 15, 2026