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Background Autism spectrum disorder (autism) describes a heterogeneous neurodevelopmental phenotype arising from the interplay of environmental and genetic factors in early life. Methods In a general population birth cohort, we employed a scoping approach to identify prospective associations between prenatal and birth factors and a subsequent autism diagnosis. Results Factors associated with increased likelihood of autism included those related to i) maternal health (maternal pre-pregnancy...
Autism
Holland L, Drummond K, Thomson S, Sominsky L, Marx W, Love C, Dawson SL, Harrison LC, Saffery R, Symeonides C, Tang ML, Burgner D, Sly PD, Vuillermin P, Ponsonby AL, BIS Investigator group•
ABSTRACT Importance Infantile dilated cardiomyopathy (DCM) associated with left bundle branch block (LBBB) is a rare but life‐threatening condition, especially when severe heart failure is present. Identifying effective solutions to improve the prognosis is crucial. Objective This study aims to evaluate the short‐term clinical outcomes and cardiac functional changes in infants with LBBB‐associated DCM treated with a combined approach of electrical and mechanical cardiac resynchronization. M...
Heart Failure And Cardiomyopathy
Zeng M, Yang F, Li Q, Ma K, Dou Z, Pang K, Lin X, Li S, Wang X•
Background: High-risk (HR) human papillomavirus (HPV) infection remains a great concern in sub-Saharan Africa in men who have sex with men (MSM). The prevalence of anal shedding of HPV and associated risk factors was estimated for the first time in a cross-sectional observational study covering MSM living in N’Djamena, the capital city of Chad. Methods: MSM were recruited from the community in 21 sites in neighborhoods of 5 districts randomly selected in N’Djamena by respondent-driven sampling (...
Glucagon-like peptide-1 (GLP-1)-based medications, such as semaglutide and tirzepatide, have transformed obesity care. However, rising use brings concerns about side effects, long-term outcomes, and unregulated products. Ensuring safe access requires oversight, monitoring, and coordinated clinical care. In this Perspective, Ariana Chao, Adam Gilden and Thomas Wadden discuss why alongside the rising popularity of glucagon-like peptide 1 (GLP-1)-based medications for obesity, there are also conce...
Purpose: The objective of this study was to systematically review the effectiveness of thoracic-focused interventions, including breathing exercises and thoracic manual techniques (mobilization, high-velocity low-amplitude manipulation, and release techniques), on pain and disability in patients with low back pain (LBP). Methods: PubMed, Scopus, Web of Sciences, ProQuest, Ovid, Physiotherapy Evidence Database (PEDro), Cochrane Central Register of Controlled Clinical Trials (CENTRAL), and Google...
Psychological assessments play a significant role in both clinical decision-making and the interpretation of research findings, with the quality of these inferences depending on the validity of the measures used. Recent evidence suggests there are gender differences in the presentation of autism, raising concerns about the validity of existing autism tools to measure autistic traits in women and the subsequent implications for clinical inferences and research. This study explored the perspective...
ABSTRACT Here, we present the closed genome sequences of nine representative clinical Listeria monocytogenes isolates from nine invasive listeriosis outbreaks in Germany that were associated with contaminated salmon products. More than half of the genomes contained two or more intact prophages.
Epigenetic studies face persistent challenges related to small sample sizes, particularly when using epigenome-wide array technologies. Presumably it is this limitation that has hindered the discovery of replicable and robust findings, much like the early struggles of genome-wide association studies. To address this gap, we conducted one of the largest epigenetic investigations of generalized anxiety disorder (GAD) using 43,504 participant’s data from the Million Veteran Program. Our analysis as...
Generalized Anxiety Disorder
Gupta P, Liu S, Galimberti M, Beck S, Adhikari K, Dao C, Nunez YZ, Overstreet C, Bright U, VA Million Veteran Program, Stein MB, Pathak GA, Shen X, Gelernter J, Levey DF•
Background: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder with existing treatment challenges, and research on the combined therapy of methylphenidate hydrochloride and sensory integration training for it is inconclusive. Thus, this study explored the clinical efficacy of this combined treatment in children with ADHD, finding it significantly improved relevant scores and reduced adverse reactions, suggesting its potential for wider use. Methods: From June 20...
Background Severe hypertriglyceridemia (HTG) in pregnancy can lead to adverse outcomes such as preeclampsia, preterm delivery, and pancreatitis. However, there are no official management guidelines for gestational HTG. Case Summary A 33-year-old woman at 32 weeks of gestation presented to the lipid clinic for severe HTG. With a multidisciplinary care team, a treatment plan including fenofibrates and icosapent ethyl was initiated. The treatment plan successfully reduced triglycerides and led t...
Background Gastroesophageal reflux disease (GERD) affects 6.8 million individuals in Spain, incurring €56 million/year in healthcare costs. Standard-of-care treatment (SOC) in Spain includes medical management with proton pump inhibitors (PPIs) and laparoscopic Nissen fundoplication (LNF) in selected cases. The limitations of PPIs, including high rates of unresponsiveness, adverse events (AEs) associated with long-term use, and nonindicative misuse, increase the economic strain on European heal...
Dear Editor, Cutaneous Lupus Erythematosus (CLE) is an autoimmune disease with variable clinical expression. It may present as an exclusively cutaneous condition or as one of the multiple manifestations of Systemic Lupus Erythematosus (SLE). Discoid Lupus Erythematosus (DLE) is the most common form of chronic cutaneous lupus erythematosus. Lesions typically affect photoexposed areas and appear as indurated erythematous plaques that evolve with follicular hyperkeratosis, atrophy, and central hyp...
Discoid Lupus Erythematosus
Ramos J, Leme H, Magarreiro-Silva A•
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